EVALUATION OF TOPICAL OZONE THERAPY ON HEALING OF MANDIBULAR BONY DEFECTS
Introduction: The use of ozone gel is an effective antioxidant, antimicrobial and anti-inflammatory agent. Moreover, it has multiple biological effects including improvement of wound healing and bone formation at surgical defects.
Objective: To evaluate the histological effect of topical administration of ozone therapy; on healing of experimentally-induced mandibular bone defects; in dogs.
Materials and methods: A split mouth design was carried out below the 4th mandibular premolar of six healthy mongrel dogs. A total of 12 bony defects were surgically created. After reflecting the mucoperiosteal flap, the defects in the rights side were treated with ozonated gel and those in the left side did not receive any treatment. Two dogs were sacrificed after 2, 6, 12 weeks. Samples were dissected and prepared for histological evaluation
Results: The study revealed that using ozone gel in bony mandibular defects accelerate the onset of new bone formation and increase vascularization at the injured site.
Conclusions: ozone is a beneficial agent for the patients to avoid possible complications and to have better chance for soft and hard tissue healing.
Key Words: ozone gel, bony defect, histological examination.