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INTRODUCTION: The development of bioactive surgical additives to regulate the inflammation and increase the speed of the healing process
is one of the greatest challenges in clinical research. Various materials and techniques have been developed to enhance the process of fracture
bone healing and to fasten it.
Numerous techniques using autologous platelet concentrates have been developed and applied; platelet rich fibrin [PRF] being one of them,
one that is completely autogenous in nature, simple and relatively inexpensive with a specific three-dimensional architecture of the fibrin. PRF
has also shown increased levels of numerous cytokines and growth factors that influence bony regeneration.
OBJECTIVES: The aim in this study was to compare between fracture healing using miniplates with and without PRF membrane in bilateral
mandibular fractures clinically and radiographically.
MATERIALS AND METHODS: all twelve patients had bilateral mandibular fractures. Each patient was treated as follows: (Study Group):
The mandibular fracture on the right side was treated by using the conventional 2.0 mm miniplates and screws with placement of PRF
membrane. (Control Group): The mandibular fracture on the left side was treated by using the conventional 2.0 mm miniplates and screws.
Follow-up was carried out every week during the first month, then at three months, and six months postoperatively.
RESULTS: none of the patients in either of the groups had an infection or signs of nonunion within the follow- up period. There was no
statistically significant difference in the mean value of pain score between the fractures in the two groups. In both groups, edema was limited
to the area of operation and resolved completely by the end of 4th week postoperatively. On immediate, 3 and 6 months postoperatively, the
mean bone density in the study group was statistically significantly higher than the control group, but the percentage change in the bone density
from immediate postoperative to 3 months, immediate postoperative to 6 months and from 3 to 6 months was not statistically significant
comparing the two groups
CONCLUSIONS: PRF application on the fracture line in the mandible may be helpful in improvement of the fracture healing but comparing
the two groups, the pattern of improvement was nearly the same along time.
KEYWORDS: Alveolar bone, Fish oil, Induced rheumatoid arthritis, Freund's complete adjuvant