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INTRODUCTION: Alveolar ridge preservation strategies are indicated to minimize the loss of ridge volume that typically follows tooth
extraction. Dentin and bone are mineralized tissues and almost similar in chemical components. Particulate dentin has a plenty of growth
factors such as bone morphogenetic proteins (BMP) that can induce new bone formation. Platelets play a fundamental role in hemostasis and
are a natural source of growth factors. Mixture of particulate dentin and platelet-rich plasma can have an osteoinductive effect during
different stages of bone healing.
OBJECTIVES: To investigate the biological effect of autogenous dentin graft combined with platelet rich plasma on alveolar bone healing
following tooth extraction in rabbit.
MATERIALS AND METHODS: Seven healthy male New Zealand rabbits weighing 3kg (±250 g) were included in this study. The upper
right incisor of each rabbit was extracted .The root of each incisor was used as a source of dentin. Root dentin was ground into powder by
means of mortar and pestle.2 ml blood were taken from each rabbit. Platelet rich plasma was separated from other blood components by
centrifuge machine. The left and right lower first premolars were extracted at the same time .The sockets of the lower right first premolars
were filled by the mixture of dentin and platelet rich plasma (study group) while sockets of the lower left premolars were left to heal
spontaneously (control group). Comparison of the healing features between the two groups was made histologically and
histomorhometrically after 6 weeks.
RESULTS: New bone formation was noticed in the sockets loaded with dentin and platelet rich plasma mixture. The newly formed bone
was significantly higher when compared to that in the control group.
CONCLUSIONS combination of dentin and platelet rich plasma induces new bone formation.
KEYWORDS: Bone regeneration, platelet rich plasma, histomorphometry, particulate dentin